The Effect of Proton Pump Inhibitor on Healing of Post-esophageal Variceal Ligation Ulcers / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 232-240, 2008.
Article
in Korean
| WPRIM
| ID: wpr-29346
ABSTRACT
BACKGROUNE/AIMS:
Esophageal variceal ligation (EVL) is the most preferable method for controling variceal bleeding. However, EVL is associated with complications such as hemorrhage, chest pain, dysphagia, and odynophagia due to post-EVL ulcers in the esophageal mucosa. The aim of this study was to assess the effect of proton pump inhibitor (PPI), pantoprazole on the healing of post-EVL ulcers.METHODS:
Forty seven patients were randomly allocated into PPI group and control group. Patients in PPI group received 40 mg of pantoprazole intravenously for 3 days after EVL, then 40 mg of oral pantoprazole for 11 days consecutively. Control patients received intravenous and oral placebo. Endoscopic examinations were performed twice at 7+/-2 days and 14+/-2 days after EVL respectively. Clinical outcomes include the size of ulcers, symptoms reported by patients; chest pain, dysphagia, and odynophagia.RESULTS:
Forty seven patients completed the 7 days protocol (PPI/control; 25/22), and twenty six patients completed the 14 days protocol (PPI/control; 16/10). Post-EVL ulcers in PPI group were significantly smaller than those in control group (7 days; 98.7 mm2/119.4 mm2, 14 days; 32.3 mm2/43.8 mm2, p0.05). Nineteen patients (PPI/control; 9/10) did not complete the 14 days protocol due to patients' refusal and adverse outcomes, such as hepatic failure and sepsis with bleeding from post-EVL ulcer occurred in two patients of control group.CONCLUSIONS:
PPI treatment following EVL may be effective in healing post-EVL ulcer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ulcer
/
Esophageal and Gastric Varices
/
Regression Analysis
/
Esophagoscopy
/
Sickness Impact Profile
/
2-Pyridinylmethylsulfinylbenzimidazoles
/
Proton Pump Inhibitors
/
Gastrointestinal Hemorrhage
/
Ligation
/
Anti-Ulcer Agents
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Practice guideline
Limits:
Female
/
Humans
/
Male
Language:
Korean
Journal:
The Korean Journal of Gastroenterology
Year:
2008
Type:
Article
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