Expression of VEGFR-2 and VEGFR-3 in papillary renal cell carcinoma and their relationship with prognosis / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 752-756, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-293489
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of VEGF receptors in papillary renal cell carcinoma and to explore the correlation between their expression and clinical prognosis.</p><p><b>METHODS</b>Expression of VEGF receptors and PCNA (proliferating cell nuclear antigen) were evaluated in 82 patients with papillary renal cell carcinoma using tissue microarray and SP immunohistochemical staining.</p><p><b>RESULTS</b>The expression of VEGFR-1 in papillary renal cell carcinoma was 82.93%, VEGFR-2 63.41%, VEGFR-3 34.15% and PCNA 67.07%, respectively. Increased VEGFR-2 expression was significantly correlated with tumor size (P = 0.016), histological grade (P = 0.034) and distant metastasis (P = 0.002). VEGFR-3 expression was correlated with histological grade (P = 0.028), lymph node status (P = 0.010) and distant metastasis (P = 0.018), but not correlated with gender, age, location, tumor size and TNM staging. VEGFR-1 expression had no correlation with any clinic and pathologic factors. PCNA expression was correlated with histological grade (P = 0.011), but not correlated with other factors. The expression of VEGFR-2 and VEGFR-3 in death cases were higher than that in surviving patients.</p><p><b>CONCLUSION</b>Both VEGFR-2 and VEGFR-3 can serve as markers for prognosis of papillary renal cell carcinoma. Differently, VEGFR-3 is a predictor of lymph node metastasis, increased VEGFR-2 expression could be used to predict a potential blood dissemination.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Carcinoma, Papillary
/
Carcinoma, Renal Cell
/
Proportional Hazards Models
/
Survival Rate
/
Proliferating Cell Nuclear Antigen
/
Vascular Endothelial Growth Factor Receptor-1
/
Vascular Endothelial Growth Factor Receptor-2
/
Vascular Endothelial Growth Factor Receptor-3
Type of study:
Prognostic study
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2010
Type:
Article
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