Therapeutic effect of interleukin-11 on thrombocytopenia in patients with hematologic malignancies after chemotherapy / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 713-715, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-293519
ABSTRACT
<p><b>OBJECTIVE</b>To investigate and evaluate the clinical therapeutic effect of low-dose interleukin-11 treatment of thrombocytopenia in patients with malignant hematologic diseases after chemotherapy.</p><p><b>METHODS</b>70 patients with hematologic malignancies including acute leukemia, lymphoma and multiple myeloma were randomly divided into treatment group (35 cases) and control group (35 cases) and were treated with chemotherapy. Cases in the treatment group received subcutaneous injection of interleukin-11 (50 µg × kg(-1) × d(-1)) until platelet counting recovered ≥ 50 × 10(9)/L, while cases in the control group were not administrated with interleukin-11.</p><p><b>RESULTS</b>The mean time of platelet recovery in the treatment group was 9.6 days, significantly shorter than that (14.0 days) in the control group (P < 0.05). The minimum platelet counting in the treatment group was significantly higher than that in the control group (16.2 × 10(9)/L vs. 11.6 × 10(9)/L, P < 0.05). The mean times of platelet infusion after chemotherapy in the treatment group and control group were 2.88 and 2.98, respectively (P > 0.05).</p><p><b>CONCLUSION</b>Administration of interleukin-11 in thrombocytopenic patients with hematologic malignancies after chemotherapy may not only remarkably enhance platelet counts and shorten the recovery time of thrombocytopenia, but also has only mild side effects.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Platelet Count
/
Therapeutics
/
Thrombocytopenia
/
Leukemia
/
Antineoplastic Combined Chemotherapy Protocols
/
Interleukin-11
/
Therapeutic Uses
/
Drug Therapy
/
Lymphoma
/
Multiple Myeloma
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2010
Type:
Article
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