Expression of microRNA-31 and its clinicopathologic significance in oral squamous cell carcinoma / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 481-484, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-293577
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of microRNA-31 and its association with clinicopathologic features in oral squamous cell carcinoma (OSCC).</p><p><b>METHODS</b>The expression level of microRNA-31 in 62 cases of OSCC and matched non-tumor adjacent tissue specimens was examined using stem-loop real-time PCR. The relationship between the expression of microRNA-31 and its clinicopathologic features of OSCC was analyzed.</p><p><b>RESULTS</b>The expression of microRNA-31 was significantly higher in the tumor tissues than that in the adjacent tissues (P < 0.05).Up-regulated microRNA-31 expression was associated with the lymph node metastasis (P < 0.05) and cell differentiation (P < 0.05) in OSCC patients.No significant association was found between the expression of microRNA-31 and gender, age, lymph node metastasis, tumor size and location.Receiver operator characteristic curve (ROC) of microRNA-31 about cell differentiation resulted in a diagnostic sensitivity of 70.4% and specificity of 89.5%.</p><p><b>CONCLUSIONS</b>The up-regulated level of microRNA-31 expression may be related to the pathogenesis of OSCC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Cell Differentiation
/
Up-Regulation
/
MicroRNAs
/
Lymphatic Metastasis
/
Metabolism
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Stomatology
Year:
2013
Type:
Article
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