Anti-mutagenesis effects of total flavonoids of Astragalus / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the anti-mutagenic action of the total flavonoids of Astragalus (TFA).</p><p><b>METHOD</b>Three groups of concentrations of TFA and one inducer group were used. The anti-mutagenic action of TFA was studied by experiments in vitro and in vivo including miconucleolus assay, semen teraogenesis test and gene mutagenesis of V79/HGPRT.</p><p><b>RESULT</b>TFA did not affect the weight of the mice during the experiment period. The high concentration of TFA could significantly reduce cyclohophamide-induced miconucleolus number and gene mutagenesis of V79/HGPRT compared with inducer group. However, TFA did not make statistic change in the semen teraogenesis induced by mitomycin C.</p><p><b>CONCLUSION</b>TFA has antimutagenesis effect.</p>