The effects of herb lithospermum extract on MCF-7 cell and estrogen and progestogen levels in mice / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effects of lithospermum extract on MCF-7 cell and estrogen and progestogen levels in mice.</p><p><b>METHOD</b>Cell growth curve and Western Blotting were used to do animal experiment.</p><p><b>RESULT</b>Lithospermum extract could inhibit the growth of MCF-7 cell. It could also inhibit the expression of ER and increase the expression of PR with large dose. After the mice were bred with Lithospermum, their serum estrogen and progestogen levels reduced, their uterus weight index decresed and uterus ER and PR levels increased. It could also improve the hyperplasia of uterus caused by tamoxifen.</p><p><b>CONCLUSION</b>Lithospermum extract can inhibit the growth of MCF-7 cell and inhibit the level of estrogen and progestogen in mice.</p>