Effect of guizhi tang and its active components on the fever induced by EP3 agonist / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1056-1060, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-293727
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Guizhi Tang and its active components on the fever induced by EP3 receptor agonist sulprostone in rats.</p><p><b>METHOD</b>The rise in body temperature evoked by a LCV(lateral cerebroventricle)-injection of sulprostone was compared with that of sulprostone induced-fever rats pretreated with Guizgi Tang and its active compounds, cinnamaldehyde, cinnamic acid and total glucosides of paeony.</p><p><b>RESULT</b>Pretreatments with Guizhi Tang and cinnamaldehyde inhibited the rise in body temperature induced by sulprostone, while cinnamic acid tended to augment the fever. The sulprostone-induced fever was blocked by an ip pretreatment of total glucosides of paeony even below the basement.</p><p><b>CONCLUSION</b>Present data suggest that interruption with the down-stream events of EP3 receptor may contribute to the antipyretic action of Guizhi Tang, cinnamaldehyde and the total glucosides of paeony, while cinnamic acid may have no such effect.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Plants, Medicinal
/
Acrolein
/
Body Temperature
/
Drugs, Chinese Herbal
/
Dinoprostone
/
Chemistry
/
Cinnamates
/
Rats, Wistar
/
Receptors, Prostaglandin E
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2003
Type:
Article
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