A novel autoantibody in patients with primary hypertension: antibody against L-type Ca2+ channel / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1513-1517, 2008.
Article
in English
| WPRIM
| ID: wpr-293968
ABSTRACT
<p><b>BACKGROUND</b>Recently, it has been proposed that the autoantibodies against various cardiovascular receptors play a role in the pathogenesis of primary hypertension. In this study, we aimed to identify whether or not there are autoantibodies against cardiovascular L-type Ca2+ channels in patients with primary hypertension.</p><p><b>METHODS</b>A peptide corresponding to the sequence 2-16 of the alpha1c-subunit of L-type Ca2+ channel was used as an antigen to screen the autoantibodies from 90 patients with primary hypertension and 45 healthy controls by an enzyme-linked immunosorbent assay (ELISA). The clinical data of 90 hypertensive patients were compared between patients with and without these autoantibodies.</p><p><b>RESULTS</b>Serum from 3 (6.7%) of the 45 healthy controls, 33 (36.7%) of 90 hypertensives showed positive responses in ELISA (P < 0.01). The prevalence of such autoantibodies in two subgroups of hypertensives with coronary heart disease (9/21, 57.14%, P < 0.05) and left ventricular diastolic dysfunction (28/63, 44.4%, P < 0.05) was higher than in those without the corresponding complications. And the patients with such autoantibodies had lower E/A than patients without such autoantibodies (0.803 +/- 0.191 vs. 1.004 +/- 0.322, P = 0.002).</p><p><b>CONCLUSION</b>There are autoantibodies against vascular L-type Ca2+ channels in patients with primary hypertension.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoantibodies
/
Blood
/
Molecular Sequence Data
/
Echocardiography
/
Amino Acid Sequence
/
Rats, Sprague-Dawley
/
Calcium Channels, L-Type
/
Allergy and Immunology
/
Hypertension
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2008
Type:
Article
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