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An approach to determine critical process parameters for ethanol precipitation process of danhong injection / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 1672-1675, 2013.
Article in Chinese | WPRIM | ID: wpr-294045
ABSTRACT
<p><b>OBJECTIVE</b>To establish a method integrating multi-targets for determining critical process parameters of the manufacturing process of traditional Chinese medicine.</p><p><b>METHOD</b>The ethanol precipitation process of Danhong injection was taken as an application case of the method established. Fractional factorial design of experiments were conducted. Mathematical models relating seven process parameters to ten targets in the ethanol precipitation process were established. Then the sums of the absolute values of the regression coefficients in the models were used to evaluate the criticality of process parameters.</p><p><b>RESULT</b>Water content in the concentrate, ethanol concentration and ethanol consumption were identified as the critical process parameters.</p><p><b>CONCLUSION</b>The method established can integrate multi-targets effectively for the evaluation of critical process parameters.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Chemical Precipitation / Drugs, Chinese Herbal / Chemistry / Chemistry, Pharmaceutical / Salvia miltiorrhiza / Methods Type of study: Prognostic study Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Chemical Precipitation / Drugs, Chinese Herbal / Chemistry / Chemistry, Pharmaceutical / Salvia miltiorrhiza / Methods Type of study: Prognostic study Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2013 Type: Article