Apolipoprotein E genotype in patients with Alzheimer's disease / 中华医学杂志(英文版)

ABSTRACT

<p><b>OBJECTIVE</b>To explore the frequency and significance of ApoE gene polymorphisms in patients with sporadic Alzheimer's disease (AD).</p><p><b>METHODS</b>Single nucleotide polymorphisms of the ApoE gene were analyzed in 32 cases of AD and 26 controls, using PCR and gene sequencing.</p><p><b>RESULTS</b>The single nucleotide polymorphism of ApoE gene 462C/G was significantly associated with AD (P < 0.05).</p><p><b>CONCLUSIONS</b>The 462C/G polymorphism might be a specific genotype in Chinese patients with sporadic AD.</p>