Involvement of dynorphin A in the inhibition of morphine physical dependence by N-nitro-L-arginine in rats / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 1055-1058, 2003.
Article
in English
| WPRIM
| ID: wpr-294171
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the involvement of immunoreactive-dynorphin A in the inhibitory effect of N-nitro-L-arginine on the morphine physical dependence in rats.</p><p><b>METHODS</b>The rats were rendered dependent on morphine by subcutaneous administration of morphine solution three times daily in a manner of dose increment of 5 mg.kg(-1) for 6 days. The degree of morphine physical dependence was monitored by scoring the abstinence syndromes precipitated by 5 mg.kg(-1) naloxone of the rats. The expression levels of immunoreactive dynorphin A in tissues were determined using a radioimmunoassay.</p><p><b>RESULTS</b>Intraperitoneal injection of 5 mg.kg(-1) N-nitro-L-arginine suppresses most of the withdrawal symptoms of morphine dependent rats. N-nitro-L-arginine can elevate the expression of immunoreactive dynorphin.</p><p><b>CONCLUSIONS</b>Chronic N-nitro-L-arginine administration can inhibit the development of morphine physical dependence in a manner of dose-dependence, which is significantly related to its role of regulating the endogeneous dynorphin system.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Dynorphins
/
Pharmacokinetics
/
Rats, Sprague-Dawley
/
Nitroarginine
/
Dose-Response Relationship, Drug
/
Morphine Dependence
Limits:
Animals
Language:
English
Journal:
Chinese Medical Journal
Year:
2003
Type:
Article
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