Effects of fosinopril and valsartan on expressions of ICAM-1 and NO in human umbilical vein endothelial cells / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 923-927, 2003.
Article
in English
| WPRIM
| ID: wpr-294202
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of fosinopril and valsartan on the expression of intercellular adhesion molecule-1 (ICAM-1) and nitric oxide (NO) induced by oxidized low-density lipoprotein (ox-LDL) in human umbilical vein endothelial cells.</p><p><b>METHODS</b>The levels of NO, ICAM-1, and nitric oxide synthase (NOS) were determined using the nitrate reductase method, ELISA, immunohistochemical and image analyses.</p><p><b>RESULTS</b>The ox-LDL can significantly increase the expression of ICAM-1 and inhibit the expression of NO and NOS in a dose-dependent manner. Fosinopril and valsartan can significantly inhibit these roles of ox-LDL. The roles of fosinopril and valsartan were not significantly different.</p><p><b>CONCLUSION</b>Fosinopril and valsartan inhibit oxidized LDL-induced expression of ICAM-1 and increase the expression of NO in human umbilical vein endothelial cells, which is one of the mechanisms of antiatherosclerosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Arteriosclerosis
/
Tetrazoles
/
Umbilical Veins
/
Valine
/
Endothelium, Vascular
/
Cells, Cultured
/
Chemistry
/
Fosinopril
/
Intercellular Adhesion Molecule-1
Limits:
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2003
Type:
Article
Similar
MEDLINE
...
LILACS
LIS