Study on the association between estrogen receptor-alpha gene polymorphisms and pubertal skeletal developmental status in China / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 540-543, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-294289
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between estrogen receptor-alpha (ER-alpha) gene polymorphisms, pubertal bone mineral density (BMD) and bone turnover markers, to better understand the frequencies of ER-a genotypes.</p><p><b>METHODS</b>The ER-alpha Pvu II and Xba I genotypes were determined by PCR-RFLP in 158 healthy adolescent girls (12-14 years old) while BMD was measured by dual-energy X-ray absorptiometry (DEXA). The bone turnover markers (BAP, BGP, TRACP) and calcium adjust hormone (25-OH-VitD, E2) were detected by ELISA. The relationship among BMD, bone turnover markers, and polymorphisms of ER-a were examined.</p><p><b>RESULTS</b>(1) Although the bone turnover markers had a trend in ER-alpha Pvu II genotypes as pp>PP>Pp but no significant difference was found (P > 0.05). There were no significant differences found among Xba I genotypes and between Px haplotype and non-Px haplotype. (2) No association was noticed between ER-a genotype and BMD at any site of the forearm and the whole body. Compared with non-Px haplotype, the Px haplotype had lower BMD, but there was no significant difference noticed (P > 0.05).</p><p><b>CONCLUSION</b>ER-alpha gene Pvu II and Xba I polymorphism seemed not potentially influence on BMD and bone turnover markers in the pubertal girls in Beijing, suggesting that it might not be the major genetic factor regarding this population.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Polymorphism, Genetic
/
Acid Phosphatase
/
Vitamin D
/
Blood
/
Bone Development
/
Haplotypes
/
Polymorphism, Restriction Fragment Length
/
Enzyme-Linked Immunosorbent Assay
/
Absorptiometry, Photon
Limits:
Adolescent
/
Child
/
Female
/
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2007
Type:
Article
Similar
MEDLINE
...
LILACS
LIS