Long-term molecular changes in WHO grade II astrocytomas following radiotherapy / 癌症
Chinese Journal of Cancer
; (12): 159-165, 2012.
Article
in En
| WPRIM
| ID: wpr-294428
Responsible library:
WPRO
ABSTRACT
Monitoring the long-term radiotherapy-associated molecular changes in low-grade gliomas (LGGs) facilitates the understanding of LGG response to radiotherapy. In this study, we used immunohistochemistry to analyze the expression of Ki-67, tumor protein P53 (TP53), P21, and P27 in 8 paired WHO grade II astrocytoma samples. The interval between radiotherapy (RT) and the second surgery was more than 3 months in all cases. The average Ki-67 labeling index (LI) was 5.3% in pre-RT samples and 11.54% in post-RT samples. Ki-67 LI was higher in the primary tumors that underwent malignant transformation observed at the second surgery after radiation. Post-RT Ki-67 LI decreased in 2 cases with an interval of less than 12 months between RT and the second surgery. TP53 expression was found in 3 out of 4 pre-RT samples with malignant transformation and in 1 out of 4 pre-RT samples without malignant transformation. Post-RT TP53 increased in 2 cases in which increased expression of P21 or P27 was also observed. Our study suggests that radiotherapy can inhibit WHO grade II astrocytoma proliferation as reflected by Ki-67 LI, but the effect attenuates with time. In addition, there is a tendency of malignant transformation for WHO grade II astrocytomas with a high Ki-67 level or TP53 expression in initial samples.
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Radiation Effects
/
Radiotherapy
/
Astrocytoma
/
General Surgery
/
Brain Neoplasms
/
Immunohistochemistry
/
Cell Transformation, Neoplastic
/
Tumor Suppressor Protein p53
/
Ki-67 Antigen
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Chinese Journal of Cancer
Year:
2012
Type:
Article