Role of ABC transporters in cancer chemotherapy / 癌症
Chinese Journal of Cancer
;
(12): 51-57, 2012.
Article
in English
| WPRIM
| ID: wpr-294431
ABSTRACT
Multidrug resistance (MDR) in cancer cells can significantly attenuate the response to chemotherapy and increase the likelihood of mortality. The major mechanism involved in conferring MDR is the overexpression of ATP-binding cassette (ABC) transporters, which can increase efflux of drugs from cancer cells, thereby decreasing intracellular drug concentration. Modulators of ABC transporters have the potential to augment the efficacy of anticancer drugs. This editorial highlights some major findings related to ABC transporters and current strategies to overcome MDR.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein-Tyrosine Kinases
/
ATP Binding Cassette Transporter, Subfamily B, Member 1
/
Drug Resistance, Multiple
/
ATP-Binding Cassette Transporters
/
Drug Resistance, Neoplasm
/
Multidrug Resistance-Associated Proteins
/
Therapeutic Uses
/
Drug Therapy
/
Nanomedicine
/
Molecular Targeted Therapy
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2012
Type:
Article
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