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Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis / 癌症
Chinese Journal of Cancer ; (12): 5-7, 2012.
Article in English | WPRIM | ID: wpr-294439
ABSTRACT
Pyruvate kinase catalyzes the rate-limiting final step of glycolysis, generating adenosine triphosphate (ATP) and pyruvate. The M2 tumor-specific isoform of pyruvate kinase (PKM2) promotes glucose uptake and lactate production in the presence of oxygen, known as aerobic glycolysis or the Warburg effect. As recently reported in Nature, PKM2, besides its metabolic function, has a nonmetabolic function in the direct control of cell cycle progression by activating β-catenin and inducing expression of the β-catenin downstream gene CCND1(encoding for cyclin D1). This nonmetabolic function of PKM2 is essential for epidermal growth factor receptor (EGFR) activation-induced tumorigenesis.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pyruvate Kinase / Cell Cycle / Cell Transformation, Neoplastic / Cyclin D1 / Cell Proliferation / Beta Catenin / ErbB Receptors / Glycolysis / Isoenzymes Limits: Animals / Humans Language: English Journal: Chinese Journal of Cancer Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Pyruvate Kinase / Cell Cycle / Cell Transformation, Neoplastic / Cyclin D1 / Cell Proliferation / Beta Catenin / ErbB Receptors / Glycolysis / Isoenzymes Limits: Animals / Humans Language: English Journal: Chinese Journal of Cancer Year: 2012 Type: Article