Modulating autophagy: a strategy for cancer therapy / 癌症
Chinese Journal of Cancer
;
(12): 655-668, 2011.
Article
in English
| WPRIM
| ID: wpr-294478
ABSTRACT
Autophagy is a process in which long-lived proteins, damaged cell organelles, and other cellular particles are sequestered and degraded. This process is important for maintaining the cellular microenvironment when the cell is under stress. Many studies have shown that autophagy plays a complex role in human diseases, especially in cancer, where it is known to have paradoxical effects. Namely, autophagy provides the energy for metabolism and tumor growth and leads to cell death that promotes tumor suppression. The link between autophagy and cancer is also evident in that some of the genes that regulate carcinogenesis, oncogenes and tumor suppressor genes, participate in or impact the autophagy process. Therefore, modulating autophagy will be a valuable topic for cancer therapy. Many studies have shown that autophagy can inhibit the tumor growth when autophagy modulators are combined with radiotherapy and/or chemotherapy. These findings suggest that autophagy may be a potent target for cancer therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Autophagy
/
Signal Transduction
/
Cell Transformation, Neoplastic
/
NF-kappa B
/
Tumor Suppressor Protein p53
/
Apoptosis
/
Drug Resistance, Neoplasm
/
Proto-Oncogene Proteins c-bcl-2
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2011
Type:
Article
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