Relationship between serum resistin level and large arterial elasticity in patients with essential hypertension / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 130-133, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-294764
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between serum resistin concentration and large arterial elasticity in patients with essential hypertension (EH).</p><p><b>METHODS</b>271 recruited subjects were divided into the control group (n = 134) and EH group (n = 137). Blood pressure, waist circumference, hip, body mass index (BMI) were measured. Serum resistin concentration was assessed by enzyme immunoassay, fasting serum insulin and TNF-alpha were measured using radioimmunity kits. Insulin resistance was evaluated by insulin resistance index (HOMA-IR). Brachial ankle pulse wave velocity (baPWV) was tested by the full-automatic arteriosclerosis diagnostic instrument.</p><p><b>RESULTS</b>(1) The serum resistin concentration, baPWV and TNF-alpha were significantly increased in EH group compared to the control group [(0.65 +/- 0.12) ng/ml vs (0.59 +/- 0.13) ng/ml; (1513.24 +/- 182.30) cm/s vs (1301.69 +/- 151.15) cm/s; (5.69 +/- 1.98) ng/ml vs (3.83 +/- 2.38) ng/ml; all P < 0.01]. (2) Pearson correlation analysis showed that resistin was positively correlated with baPWV, TNF-alpha. and HOMA-IR in EH group (r = 0.219, r = 0.212, r = 0.183, P < 0.05 respectively); partial correlation analysis revealed that resistin was positively correlated with baPWV and TNF-alpha (r = 0.238, P < 0.01; r = 0.207, P < 0.05), but not with HOMA-IR. (3) Multivariate regression analysis showed that SBP, age, TNF-alpha, resistin were risk factors of impaired baPWV in EH group (R(2) = 0.368, P < 0.01).</p><p><b>CONCLUSION</b>Large arterial elasticity was decreased in proportion to increasing serum resistin level in hypertensive patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arteries
/
Testosterone
/
Blood
/
Blood Pressure
/
Sex Factors
/
Multivariate Analysis
/
Elasticity
/
Resistin
/
Hypertension
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2009
Type:
Article
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