Haplotypes analysis of the prostacyclin synthase gene and myocardial infarction in Uigur population / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 115-119, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-294767
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between the polymorphisms and haplotypes of prostacyclin synthase gene with MI in Uigur patients in Xinjiang.</p><p><b>METHODS</b>210 patients with MI and 206 healthy control subjects were genotyped for 3 SNPs of the human prostacyclin synthase gene by polymerase chain reaction and restriction fragment length polymorphism.</p><p><b>RESULTS</b>The genotype distributions of the control group and MI group were in the Hardy-Weinberg equilibrium (both P > 0.05). The frequency of CC of rs5629 in MI group was significantly higher than that in controls (71.42% vs. 61.65%, P = 0.035). The frequency of A-C-T haplotype was significantly higher in the control group than that in the MI patients (4.01% vs. 0.60%, P = 0.001). The frequency of C-T-T haplotype was significantly higher in the MI patients than that in the controls (7.40% vs. 3.31%, P = 0.011). Logistic regression analysis showed that, after adjusting hypertension, hyperlipemia and smoking, the CC genotype of rs5629 (P = 0.021, OR = 1.665, 95%CI 1.024 - 2.156) and the C-T-T haplotype (P = 0.011, OR = 1.876, 95%CI 1.410 - 3.171) was the independent risk factors for MI.</p><p><b>CONCLUSION</b>The CC genotype of rs5629 and the C-T-T haplotype of prostacyclin synthase gene are associated with MI but the A-C-T haplotype of prostacyclin synthase gene might be a protective factor of MI in Uigur population of Xinjiang.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Haplotypes
/
Intramolecular Oxidoreductases
/
Polymorphism, Single Nucleotide
/
Cytochrome P-450 Enzyme System
/
Asian People
/
Ethnology
/
Gene Frequency
/
Genetics
/
Genotype
/
Myocardial Infarction
Type of study:
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2009
Type:
Article
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