Rosuvastatin attenuates vascular endothelial adhesiveness in apolipoprotein E-deficient mice / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 69-72, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-294776
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the anti-inflammatory effects on the vessel wall of rosuvastatin in apolipoprotein E-deficient mice.</p><p><b>METHODS</b>Eight-week-old apolipoprotein E-deficient mice fed a normal chow diet were treated with vehicle or various doses of rosuvastatin (1, 5, or 20 mg/kg) by subcutaneous injection for 2 or 6 weeks prior to sacrifice. Endothelial adhesiveness for monocytes was determined by functional binding assay. The expressions of vascular cell adhesion molecule-1 and monocyte chemotactic protein-1 in the vessel wall were detected by quantitative real-time polymerase chain reaction.</p><p><b>RESULTS</b>Endothelial adhesiveness for monocytes was significantly attenuated after 2 or 6 weeks treatments with 5 or 20 mg/kg rosuvastatin. Rosuvastatin also significantly reduced the expressions of vascular cell adhesion molecule-1 and monocyte chemotactic protein-1 in the vessel wall.</p><p><b>CONCLUSION</b>The anti-inflammatory effects of suvastatin might be responsible for attenuating the pathogenesis of atherogenesis in apolipoprotein E-deficient mice.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Apolipoproteins E
/
Pharmacology
/
Pyrimidines
/
Sulfonamides
/
Endothelium, Vascular
/
Monocytes
/
Cell Adhesion
/
Mice, Knockout
/
Vascular Cell Adhesion Molecule-1
/
Cell Biology
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2009
Type:
Article
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