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cDNA microarray technique on screening multi-drug resistance-related genes of human non-small cell lung cancer / 中国肺癌杂志
Chinese Journal of Lung Cancer ; (12): 322-325, 2010.
Article in Chinese | WPRIM | ID: wpr-294813
ABSTRACT
<p><b>BACKGROUND AND OBJECTIVE</b>The aim of this study is to screen for multi-drug resistance-related genes of human non-small cell lung cancer (NSCLC), and provide the evidences for drug-sensitive predicting genes of different NSCLC patients treated with chemotherapeutic drugs.</p><p><b>METHODS</b>Sensitivity and inhibition ratio of five antitumor drugs (NVB, GEM, TAL, DOC, CDDP) on 75 fresh NSCLC samples from different individuals were studied by means of culturing primary tumor cells and MTT assay. After the five chemotherapeutic drugs were used, multi-drug resistance-related genes of NSCLC with cDNA microarry on the samples which were all high sensitive and those resistant were screened.</p><p><b>RESULTS</b>cDNA microarray analysis screened out 212 genes, 168 of which were up-regulated while the other 44 were down-regulated in the group of highly sensitive compared with the group of resistance.</p><p><b>CONCLUSION</b>The multi-drug resistance of NSCLC may be correlative with the 212 genes screened by cDNA microarray; the detailed mechanisms of the genes still need to be detected in the future.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Carcinoma, Non-Small-Cell Lung / Drug Resistance, Neoplasm / Oligonucleotide Array Sequence Analysis / Cell Line, Tumor / Therapeutic Uses / Drug Therapy / Genetics / Lung Neoplasms / Antineoplastic Agents Type of study: Diagnostic study / Screening study Limits: Humans Language: Chinese Journal: Chinese Journal of Lung Cancer Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Carcinoma, Non-Small-Cell Lung / Drug Resistance, Neoplasm / Oligonucleotide Array Sequence Analysis / Cell Line, Tumor / Therapeutic Uses / Drug Therapy / Genetics / Lung Neoplasms / Antineoplastic Agents Type of study: Diagnostic study / Screening study Limits: Humans Language: Chinese Journal: Chinese Journal of Lung Cancer Year: 2010 Type: Article