Detection of EGFR and COX-2 expression by immunohistochemical method on a tissue microarray section in lung cancer and biological significance / 中国肺癌杂志
Chinese Journal of Lung Cancer
;
(12): 107-111, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-294850
ABSTRACT
<p><b>BACKGROUND AND OBJECTIVE</b>Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2), which can regulate growth, invasion and metastasis of tumor through relevant signaling pathway, have been detected in a variety of solid tumors. The aim of this study is to investigate the biological significance of EGFR and COX-2 expression in lung cancer and the relationship between them.</p><p><b>METHODS</b>The expression of EGFR and COX-2 was detected in 89 primary lung cancer tissues, 12 premalignant lesions, 12 lymph node metastases, and 10 normal lung tissues as the control by immunohistochemical method on a tissue microarray section.</p><p><b>RESULTS</b>EGFR protein was detectable in 59.6%, 41.7%, and 66.7% of primary lung cancer tissues, premalignant lesions and lymph node metastases, respectively; COX-2 protein was detectable in 52.8%, 41.7%, and 66.7% of primary lung cancer tissues, premalignant lesions and lymph node metastases, respectively, which were significantly higher than those of the control (P < 0.05). The positive ratios and the levels of the expression of EGFR and COX-2 proteins were closely related to histological type, clinical stage and lymph node metastasis of lung cancer (P < 0.05), but not to histological grade, sex and age (P > 0.05). COX-2 expression was related to gross type (P < 0.05). A highly positive correlation was observed between EGFR and COX-2 expression (P < 0.01).</p><p><b>CONCLUSION</b>Overexpression of EGFR and COX-2 may play an important role in the tumorgenesis, progression and malignancy of lung cancer. Detection of EGFR and COX-2 expression might be helpful to diagnosis and prognosis of lung cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Immunohistochemistry
/
Tissue Array Analysis
/
Cyclooxygenase 2
/
ErbB Receptors
/
Lung Neoplasms
/
Lymphatic Metastasis
/
Metabolism
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Lung Cancer
Year:
2010
Type:
Article
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