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Analysis of the effect of radiotherapy on malignant pleural mesothelioma when given on adjuvant or palliative basis / 中国肺癌杂志
Chinese Journal of Lung Cancer ; (12): 54-59, 2010.
Article in English | WPRIM | ID: wpr-294862
ABSTRACT
<p><b>BACKGROUND AND OBJECTIVE</b>This retrospective study was designed to evaluate the response and survival of malignant pleural mesothelioma to radiotherapy when delivered with surgery and chemotherapy and when delivered alone or with chemotherapy.</p><p><b>METHODS</b>A study for 110 patients with malignant pleural mesothelioma who presented to radiotherapy department, National Cancer Institute, Cairo and received radiation therapy in the period fromJanuary 1999 to July 2007.</p><p><b>RESULTS</b>Forty-six patients (41.8%) received trimodality therapy (surgery & adjuvant or neoadjuvant chemotherapy & adjuvant radiotherapy), while bimodality therapy (chemotherapy & radiotherapy) in 38 patients (34.5%), while 26 patients (23.6%) received single modality therapy (palliative radiotherapy), 22 patients (20%) developed local recurrence, 22 patients (20%) developed distant metastases months, 14 patients (12.7%) developed local disease progression, 25 patients (22.7%) are still alive and free of disease at time of reporting. The median survival for all patients was 16 months, while 12 and 18 months overall survival were 63.6% & 31.8% respectively while median survival for stage II, III, IV patients was 16.5, 12.5 and 8 months respectively.</p><p><b>CONCLUSION</b>Multimodality approach involving surgery, chemotherapy and radiotherapy have been evaluated and proved its superiority in improving survival, especially in stages II.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pleural Neoplasms / Radiotherapy / Survival Rate / Retrospective Studies / Mortality / Chemotherapy, Adjuvant / Combined Modality Therapy / Radiotherapy, Adjuvant / Neoadjuvant Therapy / Drug Therapy Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Chinese Journal of Lung Cancer Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pleural Neoplasms / Radiotherapy / Survival Rate / Retrospective Studies / Mortality / Chemotherapy, Adjuvant / Combined Modality Therapy / Radiotherapy, Adjuvant / Neoadjuvant Therapy / Drug Therapy Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male Language: English Journal: Chinese Journal of Lung Cancer Year: 2010 Type: Article