Serial Changes in Serum Eosinophil-associated Mediators between Atopic and Non-atopic Children after Mycoplasma pneumoniae pneumonia
Allergy, Asthma & Immunology Research
;
: 428-433, 2014.
Article
in English
| WPRIM
| ID: wpr-29487
ABSTRACT
PURPOSE:
Mycoplasma pneumoniae pneumonia (MP) is associated with the exacerbation, timing, and onset of asthma. The goal of this study was to elucidate the impact of MP on eosinophil-related hyper-reactive amplification in atopic children.METHODS:
We studied 48 patients with MP (26 atopic, 22 non-atopic), between 3 and 12 years of age. Serial changes in blood eosinophil counts, serum interleukin-5 (IL-5), and serum eosinophil cationic protein (ECP) levels were measured in atopic and non-atopic children with MP upon admission, recovery, and at 2 months post-recovery. Serum IL-5 and ECP levels were measured by enzyme-linked immunosorbent assays; eosinophil counts were measured using an autoanalyzer.RESULTS:
Serial changes in serum IL-5, ECP, and total eosinophil counts were significantly higher in atopic patients, relative to non-atopic controls (P< or =0.001). Serum IL-5 and ECP levels were significantly higher in atopic patients at all three time points tested, while eosinophil counts were higher in the clinical recovery and follow-up phases, but not in the acute phase. Furthermore, among atopic patients, serum ECP levels were significantly higher in the recovery and follow-up phases than in the acute phase.CONCLUSIONS:
The present study demonstrated significant differences in eosinophil counts, serum IL-5, and serum ECP levels between atopic and non-atopic children with MP at admission, recovery, and 2 months after clinical recovery. These outcomes are suggestive of eosinophil-related hyperreactivity in atopic children, with this status maintained for at least 2 months after MP.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pneumonia
/
Pneumonia, Mycoplasma
/
Asthma
/
Enzyme-Linked Immunosorbent Assay
/
Follow-Up Studies
/
Interleukin-5
/
Eosinophil Cationic Protein
/
Eosinophils
/
Mycoplasma pneumoniae
Type of study:
Observational study
/
Prognostic study
Limits:
Child
/
Humans
Language:
English
Journal:
Allergy, Asthma & Immunology Research
Year:
2014
Type:
Article
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