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Determination in vitro of rat plasma protein binding rate of sinomenine by using microdialysis method / 药学学报
Acta Pharmaceutica Sinica ; (12): 909-912, 2006.
Article in Chinese | WPRIM | ID: wpr-294915
ABSTRACT
<p><b>AIM</b>To determine in vitro the rat plasma protein binding rate by using microdialysis method.</p><p><b>METHODS</b>The binding rate was determined by using microdialysis probe as sampling tools and zero-net flux method as calibrating method. The regression equation was made by the difference of concentrations between the dialysis sample and the perfusate. The x-intercept of regression equation was the free drug concentration (Cf). The plasma protein binding rate was calculated by using the following equation f = ( C0 - Cf)/C0.</p><p><b>RESULT</b>The binding rate was kept relatively stable in the studied concentration range.</p><p><b>CONCLUSION</b>It is feasible that the plasma protein binding rate can be determined by using microdialysis method.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants, Medicinal / Protein Binding / Blood Proteins / Chemistry / Regression Analysis / Chromatography, High Pressure Liquid / Rats, Sprague-Dawley / Microdialysis / Sinomenium / Metabolism Type of study: Diagnostic study Limits: Animals Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2006 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Plants, Medicinal / Protein Binding / Blood Proteins / Chemistry / Regression Analysis / Chromatography, High Pressure Liquid / Rats, Sprague-Dawley / Microdialysis / Sinomenium / Metabolism Type of study: Diagnostic study Limits: Animals Language: Chinese Journal: Acta Pharmaceutica Sinica Year: 2006 Type: Article