CuZn-SOD and MDA in the serum and EPS of chronic prostatitis patients: quantitative determination and analysis / 中华男科学杂志
National Journal of Andrology
;
(12): 1012-1015, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-294974
ABSTRACT
<p><b>OBJECTIVE</b>Chronic prostatitis (CP) is a common disease in adult males. Oxidative stress injury has been found to play a significant role in the pathogenesis of CP in recent studies. This study aimed to determine the contents of CuZn-super oxide dismutase (CuZn-SOD) and malondialdehyde (MDA) in the serum and EPS in CP patients and healthy men, and investigate their significance in the diagnosis and treatment of the CP.</p><p><b>METHODS</b>A total of 120 out-patients with confirmed CP were equally divided into a type II, a type IIIA and a type IIIB group, and another 40 healthy males were included as controls. We determined the contents of CuZn-SOD and MDA in the serum and EPS of each group and compared their differences.</p><p><b>RESULTS</b>No significant differences were found in the serum CuZn-SOD content among the four groups (P > 0.05). The MDA contents were markedly higher in the CP groups than in the control (P < 0.01), but with no significant differences among the three CP groups (P > 0.05). The CuZn-SOD contents in EPS were remarkably lower in the type II and type III A than in the type III B and control groups (P < 0.01), but with no significant differences between the type II and type III A as well as between the type III B and control groups (P > 0.05). The MDA contents in EPS were markedly higher in the type II and type III A than in the type III B and control groups (P < 0.01), but with no significant differences between the type II and type III A as well as the type III B and control groups (P > 0.05).</p><p><b>CONCLUSION</b>Oxidative stress is stronger in type II and type III A CP patients than in healthy men, but has no significant difference between type III B patients and non-CP males. Determining the contents of CuZn-SOD and MDA in the serum and EPS could be very valuable for the diagnosis and assessment of chronic prostatitis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostatitis
/
Superoxide Dismutase
/
Blood
/
Case-Control Studies
/
Chronic Disease
/
Oxidative Stress
/
Malondialdehyde
/
Metabolism
Type of study:
Observational study
Limits:
Adult
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2010
Type:
Article
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