Standard doses of tadalafil for different ED patients / 中华男科学杂志
National Journal of Andrology
;
(12): 860-863, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-294985
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of different doses of tadalafil on ED, and to search for appropriate doses for the treatment of different ED patients.</p><p><b>METHODS</b>Based on the baseline peak systolic velocity (PSV) of cavernosal arteries, 136 ED patients were divided into Groups A (PSV > 15 cm/s), B (PSV > 15 cm/s), C (PSV < 15 cm/s) and D (PSV <15 cm/s) to receive oral tadalafil at 10 mg (Groups A and C) and 5 mg (Groups B and D) on alternate days for 4 weeks. All of them were scored on IIEF-5 and detected for PSVs of the bilateral cavernosal arteries by color Doppler ultrasonography and intracavernous injection of prostaglandin E1 before and after the medication.</p><p><b>RESULTS</b>After 4 weeks of tadalafil treatment, IIEF-5 scores and PSVs were remarkably improved in all the four groups as compared with the baseline (P < 0.01), significantly higher in Group C than in D (P < 0.01), but with no significant differences between A and B.</p><p><b>CONCLUSION</b>Oral tadalafil can improve PSV and hence penile erection in ED patients either at a low or a high dose. To reduce side effects and drug cost, the patients with PSV >15 cm/s can be medicated at 5 mg, while those with PSV < 15 cm/s at 10 mg or more on alternate days.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Vasodilator Agents
/
Penile Erection
/
Carbolines
/
Treatment Outcome
/
Therapeutic Uses
/
Dose-Response Relationship, Drug
/
Drug Therapy
/
Tadalafil
/
Erectile Dysfunction
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2010
Type:
Article
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