Combination of tamsulosin and tolterodine alleviates refractory lower urinary tract symptoms in male patients / 中华男科学杂志
National Journal of Andrology
;
(12): 790-793, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-294999
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate and compare the clinical efficacy and safety of the highly selective alpha receptor antagonist tamsulosin and its combination with the M receptor antagonist tolterodine in the treatment of refractory lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH).</p><p><b>METHODS</b>We included in this study 184 BPH patients with refractory LUTS with the disease course of 4 weeks to 2 years, whose LUTS were not alleviated after a week's treatment with tamsulosin. The patients were randomly divided into Groups A and B, the former (n=89) treated with tamsulosin at 0.2 mg qd and the latter (n=95) given tolterodine at 2 mg bid in addition to tamsulosin medication, both for 4 weeks. Scores on IPSS, QOL and Qmax were obtained before and after the treatment, and the improvement of LUTS evaluated after the medication.</p><p><b>RESULTS</b>The tamsulosin group showed no significant differences before and after the treatment in the scores on IPSS (13.23 +/- 4.39 vs. 12.21 +/- 4.07), QOL (4.23 +/- 1.27 vs 3.53 +/- 0.95) and Qmax ([12.3 +/- 8.39] ml/s vs. [14.1 +/- 8.62] mls) (P > 0.05), while the combination group exhibited significantly higher scores on IPSS and QOL and lower score on Qmax after the medication than before it (IPSS 14.45 +/- 5.31 vs. 6.56 +/- 2.03, P < 0.05; QOL 4.45 +/- 0.79 vs. 2.34 +/- 0.73, P < 0.05; Qmax [11.4 +/- 9.21] ml/s vs. [15.5 +/- 8.35] ml/s, P < 0.01). No severe complications were found in any of the cases.</p><p><b>CONCLUSION</b>Combination of tamsulosin and tolterodine can significantly alleviate refractory LUTS and improve QOL without causing serious adverse events in BPH patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenylpropanolamine
/
Prostatic Hyperplasia
/
Sulfonamides
/
Benzhydryl Compounds
/
Treatment Outcome
/
Muscarinic Antagonists
/
Cresols
/
Therapeutic Uses
/
Drug Therapy
/
Adrenergic alpha-1 Receptor Antagonists
Limits:
Aged
/
Aged80
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2010
Type:
Article
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