Interleukin-6-597G/A and -572C/G polymorphisms and risk of coronary heart disease / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 519-522, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-295283
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between interleukin-6 (IL-6) gene polymorphisms and the risk of coronary heart disease (CHD).</p><p><b>METHODS</b>IL-6/-597G/A and -572C/G polymorphisms were genotyped in 245 CHD patients and 260 healthy adults by PCR-RFLP. Serum IL-6 level was examined by ELISA. Logistic regression was performed to observe the relationship between IL-6/-572C/G polymorphism and other risk factors of CHD.</p><p><b>RESULTS</b>IL-6/-597G/A genotype was similar between the two groups. The frequencies of IL-6/-572C/G genotype and G allele were more frequent in patients with CHD than that in controls (P < 0.01). Compared with CC genotype, the relative risk for CHD in people with CG and GG genotypes was 1.46 (95% CI 1.01 - 2.10, P < 0.05) and 5.19 (95% CI 1.69 - 15.89, P < 0.01), respectively. The serum levels of IL-6 were similar between carriers of the IL-6/-572G allele and patients with CC genotype (P > 0.05). IL-6/-572 C/G is related to total cholesterol (OR 1.76, 95% CI 1.05 - 3.16, P < 0.05) and triglyceride (OR = 2.51, 95% CI 1.04 - 6.45, P < 0.05), respectively.</p><p><b>CONCLUSION</b>IL-6/-597G/A polymorphism was not associated with susceptibility to CHD, but IL-6-572C/G polymorphism may be a possible genetic susceptibility factor for CHD in Chinese Hans population.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood
/
Polymorphism, Restriction Fragment Length
/
Interleukin-6
/
Coronary Disease
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Alleles
/
Gene Frequency
/
Genetics
/
Genotype
Type of study:
Etiology study
/
Risk factors
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2006
Type:
Article
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