Experimental study of saikosaponin-D (SSd) on lipid peroxidation of hepatic fibrosis on rat / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effect of SSd on lipid peroxidation during experimental hepatic fibrosis progression.</p><p><b>METHOD</b>The experimental models of hepatic fibrosis were induced by intraperitoneal injection of dimethylnitrosamine (DMN) on rats. SSd was administered by intraperitoneal injection for 4 weeks. Serum was analyzed for alanine and aspartate aminotransferase (ALT and AST), hyaluronic acid (HA), laminin (LN), collagen IV (IV-C), malonaldehyde (MDA) and superoxide dismutase (SOD) activities. Liver samples were measured for MDA contents and SOD activities in normal group, model group and SSd group.</p><p><b>RESULT</b>SSd significantly decreased ALT and AST activities and lowered HA, LN and IV-C contents. It enhanced SOD activities in liver, while reduced MDA contents both in serum and liver.</p><p><b>CONCLUSION</b>SSd has obvious effects of protecting hepatocytes and resisting hepatic fibrosis, and the mechanism may be associated with its anti-lipid peroxidation effect.</p>