Experimental study of saikosaponin-D (SSd) on lipid peroxidation of hepatic fibrosis on rat / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 915-919, 2008.
Article
in Zh
| WPRIM
| ID: wpr-295440
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of SSd on lipid peroxidation during experimental hepatic fibrosis progression.</p><p><b>METHOD</b>The experimental models of hepatic fibrosis were induced by intraperitoneal injection of dimethylnitrosamine (DMN) on rats. SSd was administered by intraperitoneal injection for 4 weeks. Serum was analyzed for alanine and aspartate aminotransferase (ALT and AST), hyaluronic acid (HA), laminin (LN), collagen IV (IV-C), malonaldehyde (MDA) and superoxide dismutase (SOD) activities. Liver samples were measured for MDA contents and SOD activities in normal group, model group and SSd group.</p><p><b>RESULT</b>SSd significantly decreased ALT and AST activities and lowered HA, LN and IV-C contents. It enhanced SOD activities in liver, while reduced MDA contents both in serum and liver.</p><p><b>CONCLUSION</b>SSd has obvious effects of protecting hepatocytes and resisting hepatic fibrosis, and the mechanism may be associated with its anti-lipid peroxidation effect.</p>
Full text:
1
Index:
WPRIM
Main subject:
Oleanolic Acid
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Pharmacology
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Aspartate Aminotransferases
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Saponins
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Superoxide Dismutase
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Blood
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Lipid Peroxidation
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Laminin
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Collagen Type IV
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Therapeutic Uses
Limits:
Animals
Language:
Zh
Journal:
China Journal of Chinese Materia Medica
Year:
2008
Type:
Article