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Theoretical and experimental studies on solubility parameters of multiple components for traditional Chinese materia medica with HPLC / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 642-648, 2008.
Article in Chinese | WPRIM | ID: wpr-295468
ABSTRACT
<p><b>OBJECTIVE</b>To establish the theories and methods to determine solubility parameters of multiple components for the traditional Chinese material medica (TCMM) with HPLC.</p><p><b>METHOD</b>The mathematical expresses to determin the solubility parameters were established according to chromatographic and Hildebrand-Scatchard theories, The HPLC experiments were carried out at 40 degrees C on an Alltech Apollo C18 column (4.6 mm x 250 mm, 5 microm) eluted with acetone and water in gradient mode. The flow rate was 1.0 mL min(-1), and the detection wavelength was 254 nm. The injection volume was 1 0 microL.</p><p><b>RESULT</b>The mathematical expresses between the retention time and the solubility parameters were established and used to determin caffeine solubility parameter as 28.31 J(1/2) cm(-3/2) in accordance with 28.84 J(1/2) cm(-3/2) reported by literature, and those of aloe-emodin, rhein, emodin, physcione as 39.70 J(1/2) cm(-3/2), 39.08 J(1/2) cm(-3/2), 38.37 J(1/2) cm(-3/2), 36.42 J(1/2) cm(-3/2) respectively.</p><p><b>CONCLUSION</b>The retention time of HPLC can be used to determine the solubility parameters of multiple componets. The established method is useful for the compatibility rule study of traditional Chinese medicine.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Solubility / Temperature / Caffeine / Drugs, Chinese Herbal / Materia Medica / Chemistry / Regression Analysis / Chromatography, High Pressure Liquid / Anthraquinones / Emodin Type of study: Diagnostic study Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Solubility / Temperature / Caffeine / Drugs, Chinese Herbal / Materia Medica / Chemistry / Regression Analysis / Chromatography, High Pressure Liquid / Anthraquinones / Emodin Type of study: Diagnostic study Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2008 Type: Article