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Correlation between serum anti-P53 and familial clustering of hepatocellular carcinoma in Guangxi / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 206-209, 2012.
Article in Chinese | WPRIM | ID: wpr-295506
ABSTRACT
<p><b>OBJECTIVE</b>To assess the correlation between familial clustering of hepatocellular carcinoma (HCC) and the level of anti-P53 in human serum in Guangxi.</p><p><b>METHODS</b>Enzyme-linked immunosorbent assay (ELISA) was used to detect anti-P53 in 164 members from 20 HCC families and 164 members from non-cancer control families. Univariate analysis was performed to assess the correlation between seral level of P53 antibody and familial clustering of HCC.</p><p><b>RESULTS</b>The level of P53 antibody was significantly higher in the members of HCC families than controls (Z=-3.04, P=0.002). After eliminating the interference of hepatitis B virus infection, this tendency still remains (P=0.011). And there was a significant difference between relatives of different degrees from HCC families (chi-square=11.593, P=0.021), with the expression of anti-P53 declining along with decrease in relationship coefficient. Furthermore, the number of individuals with high anti-P53 expression was also significantly greater in HCC families (95/164) than controls (71/164) (P=0.006). And the expression was rising along with the increasing HCC numbers (chi-square=16.068, P=0.000). Anti-P53 level was also greater in HCC families featuring sibling affection than parental affection (chi-square=12.679, P=0.002). Univariate analysis indicated that high expression of anti-P53 is a risk factor for development of HCC (OR=2.087, 95%CI 1.270-3.431).</p><p><b>CONCLUSION</b>High level of anti-P53 expression may be a factor for the clustering of HCC families in Guangxi, China.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Cluster Analysis / China / Family Health / Risk Factors / Tumor Suppressor Protein p53 / Carcinoma, Hepatocellular / Allergy and Immunology / Genetics / Liver Neoplasms Type of study: Etiology study / Risk factors Limits: Adolescent / Adult / Child / Female / Humans / Male Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2012 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Blood / Cluster Analysis / China / Family Health / Risk Factors / Tumor Suppressor Protein p53 / Carcinoma, Hepatocellular / Allergy and Immunology / Genetics / Liver Neoplasms Type of study: Etiology study / Risk factors Limits: Adolescent / Adult / Child / Female / Humans / Male Country/Region as subject: Asia Language: Chinese Journal: Chinese Journal of Medical Genetics Year: 2012 Type: Article