Expressional changes of neuregulin-1 gene mRNA in peripheral blood from schizophrenia patients / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
;
(6): 620-624, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-295568
ABSTRACT
<p><b>OBJECTIVE</b>To explore the effect of anti-psychotic treatment on the expression of Neuregulin-1 (NRG1) mRNA in the peripheral blood lymphocytes of schizophrenia patients.</p><p><b>METHODS</b>The NRG1 mRNA in peripheral blood lymphocytes was measured using semi-quantitative reverse transcription (RT)-PCR in 80 first-onset schizophrenia patients, 37 sibling controls and 83 non-related controls. The patients were treated with risperdone and quetiapine for 4 weeks. Positive and negative symptom scale (PANSS) was used to evaluate the severity and clinical efficacy.</p><p><b>RESULTS</b>Prior to the treatment, the expression of NRG1 mRNA expression was significantly lower in patients than other two groups (F=73.004, P=0.000). From the second week on, the level of NRG1 mRNA expression in patients became significantly higher than before and gradually increased, whilst no significant difference between sib and non-sib controls. Prior to the treatment, there was significant correlation (r=-0.232, P=0.038) between the level of NRG1 mRNA and PANSS scores. Four weeks after the treatment, a significant correlation between the reduction rate of PANSS and the change of NRG1 mRNA (r=0.27, P=0.016).</p><p><b>CONCLUSION</b>The expression of NRG1 gene mRNA is associated with schizophrenia. Decreased expression of NRG1 may play a role in the development of schizophrenia, which can be improved by anti-psychotic drugs.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Schizophrenia
/
Time Factors
/
Antipsychotic Agents
/
RNA, Messenger
/
Gene Expression
/
Gene Expression Regulation
/
Neuregulin-1
/
Therapeutic Uses
/
Drug Therapy
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Medical Genetics
Year:
2011
Type:
Article
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