Introduction on "case-sibling control design" / 中华流行病学杂志
Chinese Journal of Epidemiology
;
(12): 170-173, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-295582
ABSTRACT
<p><b>OBJECTIVE</b>To introduce the design and statistical methods of case-sibling control design and to analyze the published data.</p><p><b>METHODS</b>Data from an association study between the coronary heart disease and methylenetetrahydrofolate reductase gene C677T polymorphism was analyzed by the sib transmission/disequibrium test (s-TDT) and the sibship disequilibrium (SDT) methods.</p><p><b>RESULTS</b>Using s-TDT method, Z value was 0.27 with P > 0.05. The result of SDT method showed that chi-square was 0.31 with 1 df, P > 0.05. All results suggested that neither s-TDT nor SDT showed significant difference between the transmitted and untransmitted methylenetetrahydrofolate reductase gene C677T allele distributions.</p><p><b>CONCLUSION</b>Case-sibling control design might avoid population stratification by using siblings as controls thus might be used to test association and linkage between genes and disease.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Research Design
/
Case-Control Studies
/
Chi-Square Distribution
/
Epidemiologic Methods
/
Coronary Disease
/
Siblings
/
Methylenetetrahydrofolate Reductase (NADPH2)
/
Genetic Association Studies
/
Gene Frequency
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Epidemiology
Year:
2006
Type:
Article
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