Relationship between genetic polymorphisms of Interferon-gamma gene intron 1 +874 site and susceptibility of hepatitis B virus infection / 中华流行病学杂志
Chinese Journal of Epidemiology
; (12): 41-43, 2006.
Article
in Zh
| WPRIM
| ID: wpr-295608
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the possible relationship between the polymorphisms of interferon-gamma (IFN-gamma) gene intron 1 at position +874 and the susceptibility of hepatitis B virus infection.</p><p><b>METHODS</b>IFN-gamma gene single nucleotide polymorphism (intron 1 at position +874) were detected in 531 subjects including 231 chronic carrier of hepatitis B virus (group CC), 165 individuals who spontaneously recovered from HBV infection (group SR) and 135 healthy controls, by polymerase chain reaction with sequence specific primers.</p><p><b>RESULTS</b>Significant difference of IFN-gamma +874 AA genotype frequency was found between group CC (TT, TA and AA frequencies were 9.1%, 12.1% and 78.8%, respectively) and control group (TT, TA and AA frequencies were 12.6%, 23.0% and 64.4%, respectively) (chi(2) = 9.60, P = 0.008), but no significant difference found between group SR (TT, TA and AA frequencies were 13.9%, 23.7% and 62.4%, respectively) and control group (chi(2) = 0.16, P = 0.92).</p><p><b>CONCLUSION</b>There was association between IFN-gamma gene polymorphism (intron 1 at position +874) and chronic HBV infection. This study suggested the possibility that IFN-gamma gene polymorphism (intron 1 at position +874) might be important in determining an individual's susceptibility in the development of chronic HBV infection.</p>
Full text:
1
Index:
WPRIM
Main subject:
Polymorphism, Genetic
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Introns
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Carrier State
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Case-Control Studies
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Hepatitis B virus
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Polymerase Chain Reaction
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Interferon-gamma
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Hepatitis B, Chronic
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Genetic Predisposition to Disease
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Gene Frequency
Type of study:
Observational_studies
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Risk_factors_studies
Limits:
Humans
Language:
Zh
Journal:
Chinese Journal of Epidemiology
Year:
2006
Type:
Article