Small interfering RNA-based molecular therapy of cancers / 癌症
Chinese Journal of Cancer
;
(12): 488-493, 2013.
Article
in English
| WPRIM
| ID: wpr-295812
ABSTRACT
RNA interference (RNAi) has become a gold standard for validating gene function in basic life science research and provides a promising therapeutic modality for cancer and other diseases. This mini-review focuses on the potential of small interfering RNAs (siRNAs) in anticancer treatment, including the establishment and screening of cancer-associated siRNA libraries and their applications in anticancer drug target discovery and cancer therapy. This article also describes the current delivery approaches of siRNAs using lipids, polymers, and, in particular, gold nanoparticles to induce significant gene silencing and tumor growth regression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Drug Carriers
/
Genetic Therapy
/
Chemistry
/
Clinical Trials as Topic
/
Gene Targeting
/
RNA, Small Interfering
/
RNA Interference
/
Drug Evaluation, Preclinical
/
Nanoparticles
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2013
Type:
Article
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