The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China / 癌症
Chinese Journal of Cancer
;
(12): 410-414, 2013.
Article
in English
| WPRIM
| ID: wpr-295819
ABSTRACT
V-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4) has been reported to be somatically mutated in 19% of melanoma cases. To investigate the prevalence of ERBB4 mutations in melanoma patients from southern China, we analyzed 117 formalin-fixed, paraffin-embedded melanoma samples archived in the Sun Yat-sen University Cancer Center. A matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) platform was used to screen for mutations. No ERBB4 hotspot mutations were detected. Our results indicate that ERBB4 mutations may play a limited role in melanomas in China; therefore, targeting the ERBB4 mutation in melanoma patients from southern China may not be a promising strategy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin Neoplasms
/
DNA, Neoplasm
/
Paraffin Embedding
/
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
/
Asian People
/
Extremities
/
ErbB Receptors
/
Receptor, ErbB-4
/
Genetics
/
Melanoma
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2013
Type:
Article
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