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The role of stem cells in airway repair: implications for the origins of lung cancer / 癌症
Chinese Journal of Cancer ; (12): 71-74, 2013.
Article in English | WPRIM | ID: wpr-295836
ABSTRACT
Lung cancer is the leading cause of cancer-related deaths worldwide. Recently, advancements in our ability to identify and study stem cell populations in the lung have helped researchers to elucidate the central role that cells with stem cell-like properties may have in lung tumorigenesis. Much of this research has focused on the use of the airway repair model to study response to injury. In this review, we discuss the primary evidence of the role that cancer stem cells play in lung cancer development. The implications of a stem cell origin of lung cancer are reviewed, and the importance of ongoing research to identify novel therapeutic and prognostic targets is reiterated.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Regeneration / Neoplastic Stem Cells / Cell Transformation, Neoplastic / Carcinoma, Non-Small-Cell Lung / Lung Injury / Lung Neoplasms Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Chinese Journal of Cancer Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Regeneration / Neoplastic Stem Cells / Cell Transformation, Neoplastic / Carcinoma, Non-Small-Cell Lung / Lung Injury / Lung Neoplasms Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Chinese Journal of Cancer Year: 2013 Type: Article