Role of autophagy in acute myeloid leukemia therapy / 癌症
Chinese Journal of Cancer
;
(12): 130-135, 2013.
Article
in English
| WPRIM
| ID: wpr-295849
ABSTRACT
Despite its dual role in determining cell fate in a wide array of solid cancer cell lines, autophagy has been robustly shown to suppress or kill acute myeloid leukemia cells via degradation of the oncogenic fusion protein that drives leukemogenesis. However, autophagy also induces the demise of acute leukemia cells that do not express the known fusion protein, though the molecular mechanism remains elusive. Nevertheless, since it can induce cooperation with apoptosis and differentiation in response to autophagic signals, autophagy can be manipulated for a better therapy on acute myeloid leukemia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Autophagy
/
Tretinoin
/
Leukemia, Myeloid, Acute
/
Leukemia, Promyelocytic, Acute
/
Oncogene Proteins, Fusion
/
Apoptosis
/
Therapeutic Uses
/
Drug Therapy
/
Apoptosis Regulatory Proteins
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2013
Type:
Article
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