Risk factors of breast cancer in Asian women: a Meta-analysis / 中华流行病学杂志

ABSTRACT

Objective To evaluate the risk factors of breast cancer in Asian women and to provide evidences for establishing a risk assessment model. Methods Published studies concerning risk factors of breast cancer in Asian women were searched systemically and assessed by NOS (Newcastle-Ottawa Scale) items between 1995 and 2010. RevMan 4.2 software was used for data analysis and for calculating OR and its 95%CI on every risk factor. Results 27 studies including 403170 women were selected for Meta-analysis. According to NOS items, 20 studies were classified as A degree and 7 studies were evaluated as B degree. The risk factors of breast cancer and its pooled odds ratio values with statistical significance were as follows 3.00 (95%CI 1.68-5.36) when number of abortions≥3; 2.39 (95%CI 1.78-3.21 ) when with family history of breast cancer; 1.54(95%CI 1.30-1.82) when age at first live birth ≥30 (year); smoking was 1.50(95%CI 1.03-2.20); 1.48(95%CI1.20-1.83) with no live births; 1.29 (95%CI 1.12-1.47) with no breast feeding; 1.26 (1.07-1.49)with age at menarche ≤12 (year) and 1.16(95%CI 1.01-1.32) with alcohol drinking. Conclusion Number of abortions≥3, family history of breast cancer, age at first live birth ≥30 (year) ,smoking, no live births, no breast feeding, age at menarche ≤ 12 (year), and alcohol drinking were among the priorities in the establishment of breast cancer risk assessment model for Asian women.