Job stress, gene polymorphism of beta2-AR, and prevalence of hypertension / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 239-246, 2008.
Article
in English
| WPRIM
| ID: wpr-296057
ABSTRACT
<p><b>OBJECTIVE</b>To study the interactive effect of job stress and genetic susceptibility (or gene polymorphism) on hypertension.</p><p><b>METHODS</b>A cross-sectional epidemiological study was conducted in 452 workers from a thermal power plant in China. Extrinsic effort, occupational reward, and over-commitment were measured. Hypertensive patients were defined by three phases of screening, reexamination, and final diagnosis. beta2-AR genotypes and allele frequencies at amino acid positions 16 (beta2-AR-16 Arg-->Gly) and 27 (beta2-AR-27 Gln-->Glu) were identified by PCR-RFLP.</p><p><b>RESULTS</b>Job stress was related with the prevalence of hypertension in males (P < 0.05), whereas no significant relationship was found in females (P > 0.05). Differences in genotypes and allele frequencies of the beta2-AR-16 were statistically significant between the hypertension and control groups (P < 0.05), whereas those of beta2-AR-27 were not (P > 0.05). The prevalence of hypertension was higher in individuals carrying Gly16 allele than in those carrying Arg16 allele of the high job stress group (P < 0.01 or 0.05).</p><p><b>CONCLUSION</b>High job stress and polymorphism of beta2-AR-16 have an interactive effect on the prevalence of hypertension in male workers.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Power Plants
/
Psychology
/
Stress, Psychological
/
China
/
Epidemiology
/
Prevalence
/
Receptors, Adrenergic, beta-2
/
Genetic Predisposition to Disease
/
Employment
Type of study:
Prevalence study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2008
Type:
Article
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