Association of ghrelin polymorphisms with metabolic syndrome in Han Nationality Chinese / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 188-192, 2008.
Article
in English
| WPRIM
| ID: wpr-296066
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association of ghrelin gene polymorphisms with metabolic syndrome in Han Nationality Chinese.</p><p><b>METHODS</b>A total of 240 patients with metabolic syndrome and 427 adults aged above forty years were recruited. Genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism analysis.</p><p><b>RESULTS</b>The allelic frequency of the Leu72Met polymorphism was 17.3% in the patient group and 11.9% in the control group (chi2 = 7.36, P = 0.007). Metabolic syndrome was more prevalent among carriers of the Met72 variant (43.8 vs 33.1%, age- and sex-adjusted odds ratio = 1.57, P = 0.01). No Arg51Gln variants were found in our study subjects.</p><p><b>CONCLUSION</b>Rather than being associated with its individual components, Leu72Met polymorphism is associated with metabolic syndrome in the Han Nationality Chinese. Arg51Gln polymorphism is rare in the Han Nationality Chinese.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
China
/
Epidemiology
/
Genetic Predisposition to Disease
/
Metabolic Syndrome
/
Asian People
/
Ghrelin
/
Gene Frequency
/
Genetics
/
Genotype
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2008
Type:
Article
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