Evaluation of two anti-hepatitis E virus IgM kits / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 512-515, 2007.
Article
in English
| WPRIM
| ID: wpr-296091
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate two commercial anti-hepatitis E virus (HEV) IgM kits used for differential diagnosis of acute enteric viral hepatitis.</p><p><b>METHODS</b>The kit for IgM capture assay, was produced with a recombinant HEV structural protein protecting primates against experimental infection by different HEV genotypes, while the other kit for indirect ELISA was produced with recombinant structural proteins from different HEV genotypes. The serum specimens were taken from 241 cases with a confirmed or presumptive diagnosis of hepatitis A and 74 cases with a confirmed or presumptive diagnosis of hepatitis E.</p><p><b>RESULTS</b>The sensitivity and specificity of the IgM capture assay kit were 97% and 100%, respectively, and the corresponding values for the other kit were 70% and 78%, respectively.</p><p><b>CONCLUSION</b>The IgM capture assay kit has higher sensitivity and specificity in diagnosing acute enteric viral hepatitis E.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Reagent Kits, Diagnostic
/
Blood
/
Immunoglobulin M
/
Sensitivity and Specificity
/
Hepatitis E
/
Diagnosis
/
Diagnosis, Differential
/
Allergy and Immunology
Type of study:
Diagnostic study
Limits:
Humans
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2007
Type:
Article
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