CD4⁺/CD8⁻ T- cell large granular lymphocytic leukemia: one case report and literatures reviews / 中华血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>Presenting the clinical features of one patient with CD4⁺/CD8⁻ T-cell large granular lymphocytic leukemia, to improve the understanding of the disease.</p><p><b>METHODS</b>Clinical data of one patient hospitalized for skin rush and leukocytosis were analyzed, and the related literatures were reviewed.</p><p><b>RESULTS</b>The patient was hospitalized for skin rush and leukocytosis. Routine blood test showed remarkable elevated white blood cell counts and mild anemia. Subsequent hematological examination led to a diagnosis of T- cell large granular lymphocytic leukemia with CD4⁺/CD8⁻ immunophenontype.</p><p><b>CONCLUSION</b>CD3⁺/CD4⁺/CD8⁻ T- cell large granular lymphocytic leukemia is a kind of variant subtype, and is relatively rare, it has different clinical features with classic CD3⁺/CD4⁻/CD8⁺/TCRαβ⁺T- cell large granular lymphocytic leukemia, so differentiating diagnosis is of great importance.</p>