Molecular Mechanism of Glycoprotein-induced Cell-Cell Fusion of Herpesviruses / 病毒学报
Chinese Journal of Virology
;
(6): 101-107, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-296210
ABSTRACT
Herpesviridae is a large family comprising linear, double-stranded DNA viruses. Herpesviridae contains three subfamilies α-, β- and γ-herpesviruses. The glycoproteins gB, gH and gL of each subfamily form the "core fusion function" in cell-cell fusion. Other herpesviruses also need additional glycoproteins to promote fusion, such as gD of the Herpes simplex virus, gp42 of the Epstein-Barr virus, and gO or UL128-131 of the Human cytomegalovirus. In contrast, glycoproteins gM or gM/gN of herpesvirus inhibit fusion. We describe the molecular mechanisms of glycoprotein-induced fusion and entry of herpesviruses. It will be helpful to further study the pathogenic mechanism of herpesvirus.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Viral Proteins
/
Virology
/
Glycoproteins
/
Cell Fusion
/
Herpesviridae Infections
/
Genetics
/
Herpesviridae
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Virology
Year:
2016
Type:
Article
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