Research Progress in Mechanisms Associated with Latent Infection in Humans by the Cytomegalovirus / 病毒学报
Chinese Journal of Virology
;
(6): 82-87, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-296213
ABSTRACT
The human cytomegalovirus (HCMV) is a widespread herpesvirus. Virus reactivation from latency can lead to stillbirth, miscarriage, fetal anomalies, and intrauterine growth retardation. During latent infection with the HCMV, the virus can be cleared by the immune response or apoptosis of host cells. However, the HCMV has developed several strategies to manipulate expression of its genes and the microenvironment of host cells. Recent studies have shown that latent infection with the HCMV is associated with viral regulation of early expression of genes; evasion of cell death; evasion of the immune response; regulatin of non-coding RNAs. This review summarizes recent research progress on the mechanisms underpinning latent infection with the HCMV.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Viral Proteins
/
Virology
/
Virus Latency
/
Cytomegalovirus Infections
/
Cytomegalovirus
/
Allergy and Immunology
/
Genetics
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Virology
Year:
2016
Type:
Article
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