Immune Protection against H9N2 Provided by H1N1 Pre-infection in Pigs / 病毒学报
Chinese Journal of Virology
;
(6): 357-362, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-296276
ABSTRACT
To explore the impact of the history of infection by the influenza A virus subtype H1N1 on secondary infection by the influenza A virus subtype H9N2, pigs non-infected and pre-infected with H1N1 were inoculated with H9N2 in parallel to compare nasal shedding and seroconversion patterns. Unlike pigs without a background of H1N1 infection, nasal shedding was not detected in pigs pre-infected with H1N1. Both groups generated antibodies against H9N2. However, levels of H1N1 antibodies in pigs pre-infected with H1N1 increased quickly and dramatically after challenge with H9N2. Cross-reaction was not observed between H1N1 antibodies and H9N2 viruses. These findings suggest that circulation of the H1N1 virus might be a barrier to the introduction and transmission of the avian H9N2 virus, thereby delaying its adaptation in pigs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Species Specificity
/
Swine
/
Virology
/
Blood
/
Orthomyxoviridae Infections
/
Cross Reactions
/
Allergy and Immunology
/
Influenza A Virus, H1N1 Subtype
/
Influenza A Virus, H9N2 Subtype
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Virology
Year:
2015
Type:
Article
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