New Trend of tumor PET imaging radiopharmaceuticals / 한양의대학술지
Hanyang Medical Reviews
;
: 4-15, 2007.
Article
in Korean
| WPRIM
| ID: wpr-29629
ABSTRACT
Tumor PET imaging with radiopharmaceuticals plays a major role in the understanding of tumor biological information and for diagnosis of tumorswith non-invasive methods. These radiopharmaceuticals can be divided into two categories radiopharmaceuticals for metabolic process imaging and for specific receptor imaging. Most tumor imaging radiopharmaceuticals such as [18F]FDG, [18F]FLT, and [11C]choline can be trapped in tumor cells by specific metabolic processes of each radiopharmaceutical and show an increase in metabolism of tumor regions. Unlike these compounds, the hypoxia imaging adiopharmaceuticals such as [18F]FMISO and [64Cu]ATSM are trapped by oxidative metabolic mechanisms under only hypoxic conditions of tumor cells. For tumor specific receptor imaging, [18F]FES for estrogen receptor positive breast cancer may be used and recent clinical results showed the possibility of evaluating tumor therapy responseby estrogen receptor imaging with [18F]FES. This paper gives an overview of the current status of tumor PET imaging adiopharmaceuticals and the development of new lead compounds as potential radiopharmaceuticals by medicinal chemistry.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast Neoplasms
/
Chemistry, Pharmaceutical
/
Radiopharmaceuticals
/
Diagnosis
/
Estrogens
/
Hypoxia
/
Metabolism
Type of study:
Diagnostic study
Language:
Korean
Journal:
Hanyang Medical Reviews
Year:
2007
Type:
Article
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