MLL1/WDR5 complex in leukemogenesis and epigenetic regulation / 癌症
Chinese Journal of Cancer
;
(12): 240-246, 2011.
Article
in English
| WPRIM
| ID: wpr-296290
ABSTRACT
MLL1 is a histone H3Lys4 methyltransferase and forms a complex with WDR5 and other components. It plays important roles in developmental events, transcriptional regulation, and leukemogenesis. MLL1-fusion proteins resulting from chromosomal translocations are molecular hallmarks of a special type of leukemia, which occurs in over 70% infant leukemia patients and often accompanies poor prognosis. Investigations in the past years on leukemogenesis and the MLL1-WDR5 histone H3Lys4 methyltransferase complex demonstrate that epigenetic regulation is one of the key steps in development and human diseases.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Histones
/
Leukemia
/
Transcriptional Activation
/
Histone-Lysine N-Methyltransferase
/
DNA Methylation
/
Epigenesis, Genetic
/
Multiprotein Complexes
/
Myeloid-Lymphoid Leukemia Protein
/
Genetics
/
Lysine
Limits:
Animals
/
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2011
Type:
Article
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