Epigenetic disruption of cell signaling in nasopharyngeal carcinoma / 癌症
Chinese Journal of Cancer
;
(12): 231-239, 2011.
Article
in English
| WPRIM
| ID: wpr-296291
ABSTRACT
Nasopharyngeal carcinoma (NPC) is a malignancy with remarkable ethnic and geographic distribution in southern China and Southeast Asia. Alternative to genetic changes, aberrant epigenetic events disrupt multiple genes involved in cell signaling pathways through DNA methylation of promoter CpG islands and/or histone modifications. These epigenetic alterations grant cell growth advantage and contribute to the initiation and progression of NPC. In this review, we summarize the epigenetic deregulation of cell signaling in NPC tumorigenesis and highlight the importance of identifying epigenetic cell signaling regulators in NPC research. Developing pharmacologic strategies to reverse the epigenetic-silencing of cell signaling regulators might thus be useful to NPC prevention and therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Repressor Proteins
/
DNA Damage
/
Carcinoma
/
Signal Transduction
/
Cell Cycle
/
Nasopharyngeal Neoplasms
/
Tumor Suppressor Protein p53
/
Apoptosis
/
Ras Proteins
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Cancer
Year:
2011
Type:
Article
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